Post‐treatment apical periodontitis related to the technical quality of root fillings and restorations in Thai population

The aim of this study was to investigate the post‐treatment apical periodontitis in endodontically treated teeth related to the technical quality of root fillings and restorations in Thai population. Full‐mouth periapical radiographs from Thai patients attending the Faculty of Dentistry, Mahidol University, Thailand were examined. The periapical status, quality of root fillings and coronal restorations, existence of intraradicular post and its relationship to the root fillings were evaluated. Among 1586 patients, 37.4% presented endodontically treated teeth. The total number of endodontically treated teeth was 1511, and 35% presented apical periodontitis. Combined data for root filling and coronal restoration qualities revealed significantly better outcome in teeth with adequate qualities of both parameters than the other combinations (P < 0.001). The prevalence of post‐treatment apical periodontitis among Thai population was relatively high and significantly associated with substandard technical quality of root fillings and restorations.     

Impact of noradrenaline infusion set on mean arterial pressure: A retrospective clinical study

Objectives

Noradrenaline (NA) can be infused through various systems including single or double syringe pumps. The aim of this study was to define the best and most efficient infusion system in an emergency context.

Study design

This was a retrospective clinical study based on the analysis of patients’ hemodynamic data.

Patients and method

Three infusion lines used presently in our postoperative ICU were compared through a retrospective clinical study: an NA syringe pump at 2 mL/h and a saline carrier solution syringe pump at 8 mL/h (infusion system 1- IS1) or 5 mL/h (IS2), both connected to a very low dead-space volume set (V = 0.046 mL); IS3 with the same NA syringe at 2 mL/h directly connected to the central venous catheter. Mean arterial pressure (MAP) was obtained from retrospective data analysis of ICU patients with postoperative septic shock criteria. Infusion systems were compared according to the time required to reach an MAP greater than 65 mmHg after the onset of infusion.

Results

Data from 37 patients was analysed. The MAP objective was attained in 14:00 minutes (9:20 – 26:10, n = 15) with IS1, in 19:10 minutes (12:20 – 27:20, n = 13) with IS2 and in 34:10 minutes (23:10 – 62:30, n = 9) with IS3 (P = 0.00032).

Conclusion

The use of a double syringe pump system associated with a very low dead-space volume infusion set appears to be the most appropriate system for NA infusion.     

应用“倍骼生”增宽牙槽嵴的实验研究

目的 观察倍骼生（Bioglass）在牙槽嵴增宽术中诱骨成骨的作用,寻求一种优于羟基磷灰石的人工骨材料。方法 36只成年兔随机分为3组,劈开第1、2组兔的下颌骨下缘,分别植入Bioglass和羟基磷灰石（HA）,第3组为对照组。术后4周、8周、12周取术区标本进行大体观察和测量、放射学检查和组织学检查,观察其新骨形成的速度和质量。结果 Bioglass与HA组增宽下颌骨的效果明显优于对照组（P＜0．05）,其中Bioglass组诱导新骨形成的速度和质量均优于HA组。结论 Bioglass是一种用于骨修复的理想的同种异源移植材料。     

Biocompatibility and antibiofilm activity of graphene-oxide functionalized titanium discs and collagen membranes

The aims of the study were: 1) to evaluate the effect on biofilm formation of barrier membranes and titanium surfaces coated with graphene-oxide (GO); 2) to analyze the connection between the superficial topography of the tested materials and the amount of bacterial accumulation on them and 3) to analyze the biocompatibility of GO functionalized discs using the zebrafish model.MethodsSingle species bacterial biofilms (Streptococcus oralis, Veilonella parvula, Fusobacterium nucleatum, Porphyomonas gingivalis) were grown on GO-free membranes, membranes coated with 2 and 10 μg/ml of GO, GO-free and GO-coated titanium discs. The biofilms were analyzed by determining the CFU count and by Scanning Electron Microscopy (SEM) and the materials’ topography by Atomic Force Microscopy (AFM). Zebrafish model was used to determine the materials’ toxicity and inflammatory effects.ResultsAFM showed similar roughness of control and GO-coated materials. CFU counts on GO-coated discs were significantly lower than on control discs for all species. CFU counts of S. oralis, V. parvula and P. gingivalis were lower on biofilms grown on both types of GO-coated membranes than on GO-free membrane. SEM analysis showed different formation of single species biofilm of S. oralis on control and GO-coated materials.GO-functionalized titanium discs do not induce toxic or inflammatory effects.SignificanceTitanium implant surfaces functionalized with GO have shown to be biocompatible and less susceptible to biofilm formation. These results encourage further in vivo investigation of the tested materials on infection prevention, specifically in prevention and reduction of peri-implant mucositis and periimplantitis incidence.     

行经皮椎体成形术的国产骨水泥的材料性能研究

目的评估影响不同配置比例国产骨水泥材料性能的因素,探讨将其用于临床的可行性.方法将国产骨水泥按粉液比及粉剂中BaSO4含量的不同分成12组,测定其强度、刚度、聚合时最高温度以及聚合温度超过50.0 ℃及60.0 ℃以上时所持续的时间.结果随着粉液比例及粉剂中BaSO4含量的改变,骨水泥刚度、强度、聚合时最高温度随之改变(P＜0.05),而且两因素对最高温度和刚度的影响存在交互作用.但各组骨水泥聚合温度超过50.0 ℃及60.0 ℃以上所持续的时间无差异(P＞0.05).结论通过改变国产骨水泥的配比比例,可获得较满意的材料性能,从而有望在PVP术中得到应用.     

做好医院设备物资保障工作，确保地震医疗救援

汶川地震医疗救援中，华西医院设备物资科紧急抢修，保障全院医疗设备设施正常运行，发挥大型医院设备物资采购专业优势，前移物资设备供应、优化供应流程，有效保障救灾物资的供应，高效有序管理、严把质量、优化捐赠物资的应用。5月12～30日共急购医用材料220万件（支），合计金额377万元，医疗设备220台件，合计金额900万元。     

能谱CT物质分离技术克服肾囊肿伪强化的临床评估

目的 评估能谱CT物质分离技术克服肾囊肿伪强化的价值。方法 80例肾囊肿患者接受能谱GSI模式平扫及双期增强扫描,共入组75个囊肿,按囊肿大小分为3组,A组（n=25）肾囊肿直径0.5~<1.5 cm、B组（n=25）直径1.5~<2.5 cm、C组（n=25）直径2.5~<3.5 cm。采用GSIViewer分析软件生成碘、水基图,记录单能谱70 keV图像上各期肾囊肿的CT值及碘水基值,比较各组肾囊肿平扫和增强双期CT值、碘水基值、CT值和碘水基值差值的差异。结果 3组间实质期与平扫CT值差值总体差异有统计学意义（F=204.128,P<0.001）,且两两比较差异均有统计学意义（P均<0.001）。增强后A、B组实质期CT值增加均超过10HU,出现了伪强化现象,C组CT值增加小于10HU,无伪强化现象。各组肾囊肿平扫、皮质期及实质期间碘基值差异有统计学意义（P均<0.001）。3组平扫和增强双期之间碘基值的差值均在10（100 μg/cm³）内,且差值平均值A组> B组> C组（P均<0.05）。A组肾囊肿皮质期及实质期水基值低于平扫（P均<0.05）,但差值均在10 mg/cm³以内。结论 能谱CT物质分离技术测定肾囊肿各期碘、水基值时同样会发生碘水基值的"漂移",肾囊肿越小其发生"漂移"的程度越大,碘基值发生漂移的程度受肾囊肿大小的影响较水基值更明显。     

ChemFil玻璃离子材料修复乳牙龋齿的临床观察

目的评价ChemFil玻璃离子材料修复乳牙龋齿的临床疗效及实用性。方法使用3M光固化、ChemFil、增强型3种玻璃离子材料进行修复,选择263名儿童患乳牙龋齿共387颗,并于治疗后1.5～2年进行随访复查。从边缘密合度、表面磨耗情况、继发龋发生方面来观察疗效。并进行统计学分析。结果在边缘密合度和表面磨耗情况方面,3M光固化和ChemFil玻璃离子优于增强型玻璃离子（P〈0.05）;在继发龋发生方面,三者之间无显著性差异（P〉0.05）。结论ChemFil玻璃离子材料为临床上修复乳牙龋齿有效实用的方法。     

国外抗腹腔粘连材料的研究进展

抗腹腔粘连材料为近期外科临床研究的热点,因着眼点不同研究结果迥异。文中介绍了抗粘连材料的分类,针对材料的不同性质,从抗粘连的作用机制和应用局限性进行阐述,总结目前屏障材料类研究存在的问题,并对未来研究方向进行总结和展望。     

基于系统虚拟药理学复方丹参滴丸抗血小板聚集药效物质基础研究

目的:基于系统虚拟药理学研究复方丹参滴丸抗血小板聚集药效物质基础,对该复方作用效应在分子网络层面上进行探析。方法:选择了16个血小板聚集相关靶点,构建该组方化学成分分子数据库,探讨数据库分子与血小板聚集靶点间相互作用关系。结果:该组方与16个血小板聚集靶点均有一定的潜在协同效应;并应用药理学实验对部分数据进行了验证。结论:本实验从分子层次上阐释了复方丹参滴丸抗血小板聚集系统药效物质基础,为该组方的临床应用提供了科学依据;同时,也为寻找血小板聚集药物提供一定的参考和借鉴。